Thermo Fisher Scientific JMJD2C Monoclonal Antibody (OTI5B9)
JMJD2C(KDM4C) 단백질을 인식하는 고특이성 Mouse Monoclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. Affinity chromatography로 정제된 액상 형태, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B9 |
| Immunogen | Full-length protein expressed in 293T cell transfected with human KDM4C expression vector |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723299 |
Target Information
Jumonji domain-containing protein 2C (JMJD2C), also known as Lysine-specific demethylase 4C (KDM4C), is a histone demethylase that specifically demethylates Lys-9 and Lys-36 residues of histone H3, playing a central role in the histone code.
KDM4C does not demethylate histone H3 Lys-4, H3 Lys-27, or H4 Lys-20. It acts on trimethylated H3 Lys-9 and H3 Lys-36 residues but shows no activity on mono- or dimethylated forms.
Demethylation of Lys residues generates formaldehyde and succinate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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