Thermo Fisher Scientific ARK5 Polyclonal Antibody
ARK5 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 고순도 Protein A 정제, 1 mg/mL 농도, Human/Mouse/Rat 반응성. 암 침윤 및 DNA 손상 반응 연구에 적합.
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Thermo Fisher Scientific ARK5 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human ARK5, amino acids 451–550 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NUAK1 (ARK5) is a serine/threonine kinase involved in multiple cellular functions. Overexpression of this kinase is associated with tumor invasion and metastasis, particularly in colorectal neoplasms. It regulates cellular senescence and ploidy through phosphorylation of Ser-464 on LATS1, influencing its stability. Additionally, ARK5 controls cell adhesion by modulating the myosin protein phosphatase 1 (PP1) complex via phosphorylation of PPP1R12A, leading to altered myosin MLC2 dephosphorylation. It participates in DNA damage response by phosphorylating p53/TP53 at Ser-15 and Ser-392 and contributes to transcriptional activation at the CDKN1A/WAF1 promoter. ARK5 may act as a tumor malignancy-associated factor under AKT1 regulation, suppressing Fas-induced apoptosis through CASP6 phosphorylation. It also plays a role in UV-induced DNA damage response by phosphorylating CDKN1A in association with STK11, aiding its degradation for optimal DNA repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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