Thermo Fisher Scientific CCR4 Polyclonal Antibody, Biotin
CCR4 단백질을 인식하는 Biotin 결합 토끼 폴리클로날 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Affinity chromatography로 정제되었으며, 고순도와 재현성을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:100–1:250 |
| Dot Blot (DB) | 1:10,000 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Cat, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1–50 of human CCR4 (C-C chemokine receptor type 4) protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA and 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CCR4 is a chemokine receptor preferentially expressed on type 2 helper T (Th2-type) cells. Unlike other chemokine receptors, CCR4 and CCR8 expression on Th2 cells transiently increases following TCR and CD28 engagement. Activated Th1 cells also up-regulate CCR4 expression and responsiveness to thymus- and activation-regulated chemokine.
Chemokines are small (approximately 8–14 kDa), structurally related molecules that regulate leukocyte trafficking via 7-transmembrane, G protein-coupled receptors. They play key roles in immune system development, homeostasis, and function, and also affect CNS cells and endothelial cells involved in angiogenesis or angiostasis. Chemokines are classified into CXC and CC subfamilies based on cysteine residue arrangements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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