Thermo Fisher Scientific Phospho-Estrogen Receptor-a (Ser106) Polyclonal Antibody
인산화 에스트로겐 수용체-α(Ser106)를 특이적으로 인식하는 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응합니다. WB, IHC, ICC/IF에 적합하며, 단백질 A로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- 43071-100UL
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-Estrogen Receptor-a (Ser106) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence including phosphorylation site of Serine 106 (S-P-S(p)-P-L) derived from human estrogen receptor-alpha and conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | Dulbecco’s PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, induces a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can regulate gene transcription through recruitment of coactivator or corepressor proteins.
There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2). Due to alternative RNA splicing, at least four estrogen receptor-alpha isoforms are known: Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), and Isoform 4 (35 kDa). Estrogen receptors are widely expressed in various tissues and are essential for sexual development and reproductive function, as well as roles in bone and other tissues. They are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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