Thermo Fisher Scientific Androgen Receptor (AR) Polyclonal Antibody
Rabbit polyclonal antibody specific to Androgen Receptor (AR). Validated for WB and IHC-P applications. Reacts with human, mouse, and rat samples. Suitable for detecting AR localization in nucleus and cytoplasm. For research use only.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Androgen Receptor (AR) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 2–10 µg/mL |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide surrounding the epitope -EASGA- without phosphorylation |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Prostate carcinoma
- Cellular location: Nucleus, Cytoplasm
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It has three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. AR acts as a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, AR dissociates from accessory proteins, translocates to the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
AR signaling is essential for the development and function of male reproductive organs such as the prostate and epididymis, and also plays roles in muscle, hair follicles, and brain. As a phosphoprotein, AR regulates MAP kinase pathways, and its phosphorylation state is influenced by MEK1/2 pathway activity. Dysregulation of AR signaling has been linked to diseases including prostate cancer, Kennedy’s disease, male infertility, and complete androgen insensitivity syndrome (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.