Thermo Fisher Scientific RUSC1 Polyclonal Antibody
RUSC1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human RUSC1 (amino acids 281–380) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS (pH 7.4) with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure consisting of RUN, leucine zipper, and SH3 domains, with over 30% amino acid identity.
RUSC1 acts as an adaptor protein that binds to the TrkA receptor and is essential for NGF-induced neurite growth in PC12 cells. It interacts with IKK-γ (the regulatory subunit of the IKK complex) and TRAF6, influencing NF-κB activation pathways such as TNF-R and TLR signaling.
Overexpression of RUSC1 inhibits TRAF6-mediated polyubiquitination of IKK-γ, suggesting RUSC1 plays a regulatory role in NF-κB signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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