Thermo Fisher Scientific GFR alpha-1 Polyclonal Antibody
GFR alpha-1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 Immunocytochemistry에 적합합니다. 인간 GFR alpha-1의 369-382 아미노산 서열 기반 합성 펩타이드로 제조되었습니다. 뇌, 신장, 비장 시료에서 양성 대조로 권장됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide TALRVKNKPLGPAG, corresponding to amino acids 369–382 of Human GFR alpha-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2232333 |
Product Specific Information
Recommended positive controls: Crude membrane fractions of human brain, kidney, and spleen.
Target Information
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nervous system. Physiological responses to GDNF require the presence of a glycosylphosphatidylinositol-linked protein, GDNFRα, which acts as a cell surface receptor for GDNF. The cDNAs encoding GDNFRα from human, rat, chicken, and mouse have been cloned. GDNFRα, also known as Ret ligand 1 (RETL1) or TGF-β-related neurotrophic factor receptor 1 (TrnR1), is now referred to as GFRα-1. GFRα-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Together, GDNF, GFRα, and Ret PTK form a complex to transduce GDNF signaling and mediate its function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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