Thermo Fisher Scientific BID Polyclonal Antibody
인간 BID 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. 4°C에서 보관하며, 연구용으로만 사용 가능합니다.
- 카탈로그번호
- A300168Ax (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific BID Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 120 and 180 of human BH3 interacting domain death agonist (BID) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. It belongs to the BCL-2 family of cell death regulators. BID mediates mitochondrial damage induced by caspase-8 (CASP8), which cleaves this protein, allowing the COOH-terminal fragment to translocate to mitochondria and trigger cytochrome c release.
In normal cells, BID exists in an inactive cytosolic form and is activated by caspase 8 in response to TNF alpha or Fas ligand. The cleaved C-terminal 15 kDa fragment (p15) translocates to mitochondria, initiating apoptosis. BID thus serves as a molecular link between caspase 8 activation and mitochondrial death machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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