Thermo Fisher Scientific Phospho-LATS1/LATS2 (Thr1079, Thr1041) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Positive Samples: HeLa

Target Information

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. The C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor, supported by knockout mouse studies showing development of soft-tissue sarcomas, ovarian stromal cell tumors, and high sensitivity to carcinogenic treatments.

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For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.