Thermo Fisher Scientific UPAR Polyclonal Antibody
Thermo Fisher Scientific UPAR Polyclonal Antibody는 인간 uPAR(CD87)에 특이적인 토끼 다클론 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 4°C에서 보관합니다. 세포 표면 플라스미노겐 활성화 연구에 활용 가능합니다.
- 카탈로그번호
- A304463Ax (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific UPAR Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,500
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 175–225 of Human Urokinase-Type Plasminogen Activator (uPA) Receptor (uPAR, CD87, UniProt ID: Q03405-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Chimpanzee
Target Information
The urokinase-type plasminogen activator receptor (uPAR) is a key molecule regulating cell-surface plasminogen activation and plays an important role in both normal and pathological processes.
Human PLAUR cDNA encodes 335 amino acids, including a 22-residue signal peptide and a hydrophobic C-terminal portion. It forms a highly glycosylated ~50 kDa protein anchored to the plasma membrane via glycosyl-phosphatidylinositol linkage.
PLAUR (UPAR) interacts with the carbohydrate-binding domain of SELL on neutrophil membranes, analogous to its association with β2 integrins. PLAUR-mediated calcium mobilization is SELL-dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing a 33-fold increase in advanced stages compared to normal tissue.
UPAR protein expression correlates positively with recurrence and mortality rates in endometrial cancer patients, suggesting its potential as a prognostic marker for advanced endometrial cancer.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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