Thermo Fisher Scientific Nicastrin Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,500

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt

Target Information

NCSTN (Nicastrin) encodes a type I transmembrane glycoprotein that is a key component of the gamma-secretase complex.
This protein is involved in the cleavage of integral membrane proteins such as Notch receptors and beta-amyloid precursor protein.
It may act as a stabilizing cofactor for gamma-secretase complex assembly.
Mutations in NCSTN are associated with familial acne inversa.
A pseudogene is present on chromosome 21.
The role of Nicastrin in Alzheimer’s disease remains uncertain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.