Thermo Fisher Scientific MERTK Polyclonal Antibody
Thermo Fisher Scientific의 MERTK Polyclonal Antibody는 인간 MERTK 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot, ICC/IF, IP 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Immunoprecipitation (IP) | 1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 900–994 of MerTK protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.75 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris glycine, pH 7.4–7.9, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% Sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1958340 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MERTK (cMER) is a tyrosine kinase proto-oncogene involved in retinal pigment epithelium (RPE) phagocytosis, implicated in retinal disease. It regulates cell survival, migration, differentiation, and efferocytosis of apoptotic cells. Ligand binding induces autophosphorylation of MERTK, enabling downstream signaling through GRB2 or PLCG2, and phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1. MERTK signaling contributes to macrophage clearance, platelet aggregation, cytoskeleton reorganization, and inhibition of TLR-mediated innate immune response by activating STAT1 and inducing SOCS1/SOCS3 production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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