Thermo Fisher Scientific PGCF Polyclonal Antibody

Thermo Fisher Scientific PGCF Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

The PA1-31197 immunogen is a synthetic peptide for particulate guanylyl cyclase F. All peptides were amidated for conjugation. The PGCF selective antibodies were prepared against a unique peptide selective for only PGCF that maps at or close to the C-terminus.

Target Information

GUCY2F (Guanylate cyclase 2F, retinal), also known as GUC2F or RETGC2, belongs to the adenylyl cyclase class-4/guanylyl cyclase family. GUCY2F may play a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

By in situ hybridization, mRNA encoding GUCY2F is found only in the outer nuclear layer and inner segments of photoreceptor cells. Using synthetic peptide antiserum specific for each RetGC subtype, RetGC-2 (GUCY2F) can be distinguished from RetGC-1 as a slightly smaller protein in immunoblots of bovine rod outer segments.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.