Thermo Fisher Scientific TAF10 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
SNGVYVLPSA ANGDVKPVVS STPLVDFLMQ LEDYTPTIPD AVTGYYLNRA GFEASDPRII RLISLAAQKF ISDIANDALQ HCKMKGTASG SSRSKSKDRK YTLTMEDLTP ALSEYGINVK KP

Highest antigen sequence identity to the following orthologs:
Mouse – 98%, Rat – 98%.

Target Information

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals.

TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors (TAFs). TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition, or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.

This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.