Thermo Fisher Scientific Clusterin alpha Polyclonal Antibody
Thermo Fisher Scientific의 Clusterin alpha 폴리클로날 항체는 Mouse와 Rat 시료에 반응하며 Western blot 및 IHC에 사용 가능. 합성 펩타이드 항원 기반으로 제작된 Rabbit Ig 폴리클로날 형태. 동결건조 제형으로 장기 보관 시 -20°C에서 안정적. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:200–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 300–350 of mouse Clusterin conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Clusterin alpha chain.
Target Information
Isoform 1 of Clusterin prevents stress-induced aggregation of blood plasma proteins and inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro). It maintains partially unfolded proteins for subsequent refolding by other chaperones such as HSPA8/HSC70. Clusterin does not refold proteins by itself but facilitates internalization and degradation of chaperone-client complexes. Intracellular isoforms interact with ubiquitin and SCF E3 ligase complexes, promoting proteasomal degradation of target proteins such as COMMD1 and IKBKB, and modulating NF-kappa-B activity. Nuclear isoforms promote apoptosis, while mitochondrial isoforms inhibit BAX-dependent cytochrome c release and apoptosis. Plays a role in regulating cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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