Thermo Fisher Scientific Clusterin alpha Polyclonal Antibody
Thermo Fisher Scientific의 Clusterin alpha Polyclonal Antibody는 Mouse와 Rat에서 반응하며, Western blot 및 IHC에 적합한 Rabbit 유래 다클론 항체입니다. 합성 펩타이드(aa 400-448)를 면역원으로 사용하며, 동결건조 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:200–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 400–448 of mouse Clusterin conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4 °C short term. For long-term storage, store at −20 °C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Clusterin alpha chain.
Target Information
Isoform 1 of Clusterin prevents stress-induced aggregation of blood plasma proteins. It inhibits amyloid fibril formation by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro).
Clusterin acts as a molecular chaperone that maintains partially unfolded proteins for refolding by other chaperones such as HSPA8/HSC70. It does not refold proteins by itself but facilitates their internalization and degradation via lysosomal or proteasomal pathways.
Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ligase complexes, promoting ubiquitination and degradation of target proteins such as COMMD1 and IKBKB. Clusterin modulates NF-κB transcriptional activity, with nuclear isoforms promoting apoptosis and mitochondrial isoforms inhibiting BAX-dependent cytochrome c release.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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