Thermo Fisher Scientific Calbindin 1 (CALB1) Monoclonal Antibody (CALB1, 2782)

Thermo Fisher Scientific Calbindin 1 (CALB1) Monoclonal Antibody (CALB1, 2782)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

Calbindin-D-28K (also termed vitamin D-dependent calcium-binding protein or cholecalcin) is a highly conserved 28 kDa calcium-binding protein with broad tissue distribution.
It belongs to the family of low molecular weight calcium-binding proteins (CaBPs), including calmodulin, S-100, parvalbumin, and troponin C. These proteins share homologous EF-hand type polypeptide folds for Ca²⁺ binding.
Calbindin-D-28K is found predominantly in subpopulations of central and peripheral nervous system neurons and in epithelial cells involved in Ca²⁺ transport, such as distal tubular cells and cortical collecting tubules of the kidney, and in enteric neuroendocrine cells.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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