Thermo Fisher Scientific CYR61 Polyclonal Antibody
CYR61 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF 등 다양한 응용에 적합하며 Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 고농도 액상 항체로 안정적인 신호 검출 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
| ChIP assay (ChIP) | - | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human CYR61 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.34 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735700 |
Product Specific Information
- Positive Control: HeLa (1X Brefeldin A for 24 hr)
- Predicted Reactivity: Chicken (81%), Chimpanzee (99%), Bovine (92%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CYR61 is a secreted heparin-binding protein encoded by a growth factor-inducible immediate-early gene. It associates with the extracellular matrix and connective tissue and belongs to the CCN protein family, which includes CTGF and Fisp12.
As an angiogenic inducer, CYR61 binds to integrin αvβ3, stimulating cell adhesion, migration, and DNA synthesis in human vascular endothelial cells. Expression increases during vessel growth, wound healing, and chondrocyte differentiation. It is also detected in various tumors, promoting tumor growth and serving as a marker of tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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