Thermo Fisher Scientific Cdc23 Recombinant Rabbit Monoclonal Antibody (ARC2133)
Thermo Fisher Scientific의 Cdc23 Rabbit Recombinant Monoclonal Antibody (ARC2133)은 인간, 생쥐, 랫트 시료에 반응하며 WB, ICC/IF, ELISA에 적합합니다. HEK293 세포에서 발현된 고순도 항체로, CDC23 단백질의 498-597 아미노산 서열을 인식합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Cdc23 Recombinant Rabbit Monoclonal Antibody (ARC2133)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2133 |
| Immunogen | Synthetic peptide corresponding to amino acids 498–597 of human CDC23 (Q9UJX2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.55 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898075 |
Product Specific Information
- Positive Samples: HeLa, SKOV3, Jurkat, Mouse lung, Mouse brain, Mouse spleen, Rat brain
- Immunogen sequence:
YSCGEIVEHL EESTAFRYLA QYYFKCKLWD EASTCAQKCC AFNDTREEGK ALLRQILQLR NQGETPTTEV PAPFFLPASL SANNTPTRRV SPLNLSSVTP
Target Information
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s), and the ubiquitin-protein ligases (E3s).
Ubr2 (Ubiquitin-protein ligase E3-alpha-2), also known as N-recognin-2, is a 1755 amino acid protein that contains one UBR-type zinc finger and one RING-type zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr2 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins with destabilizing N-terminal residues, leading to their ubiquitination and subsequent degradation. Mice lacking Ubr2 are infertile due to defects in male meiosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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