Thermo Fisher Scientific CD71/Transferrin Receptor (TFRC) (Extracellular Domain) Monoclonal Antibody (TFRC, 1839)
인간 TFRC 단백질의 세포외 도메인을 인식하는 단클론 항체로, IHC(P) 및 Peptide Array에 사용 가능. 단백질 A/G로 정제된 액상 항체이며, 보존제 없이 PBS(pH 7.4)에 저장. 철 이온 수송 관련 연구 및 적혈구 발달 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TFRC, 1839 |
| Immunogen | Recombinant extracellular fragment (around aa 94–212) of human TFRC protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Tested in direct ELISA (use antibody at 2–4 µg/mL for coating).
- For immunohistochemistry (PFA-fixed): incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heat-induced epitope retrieval in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release, and the apotransferrin-receptor complex is recycled to the cell surface. Transferrin receptor is essential for erythrocyte and nervous system development. Serum transferrin receptor (sTfR) is used to detect erythropoietin (EPO) misuse and to diagnose various anemias associated with conditions such as rheumatoid arthritis, pregnancy, irritable bowel syndrome, and HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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