ELK Biotechnology Ribosomal Protein S6 (phospho Ser235/S236) rabbit pAb
Ribosomal Protein S6의 Ser235/236 인산화 형태를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 사용 가능하며, 세포 성장 및 단백질 합성 연구에 적합. 고순도 IgG, -20°C에서 1년 보관.
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Ribosomal Protein S6 (phospho Ser235/S236) rabbit pAb
제품 개요
Ribosomal Protein S6의 Ser235 및 Ser236 인산화 부위를 인식하는 rabbit polyclonal antibody로, 단백질 합성 조절 및 세포 성장 신호전달 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Ribosomal Protein S6 (phospho Ser235/S236) rabbit pAb |
| Alternative Names | RPS6; OK/SW-cl.2; 40S ribosomal protein S6; Phosphoprotein NP33 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/5000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human S6 Ribosomal Protein around Ser235/236 phosphorylation site (AA range: 200–249) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 30 kDa |
| Gene ID (Human) | 6194 |
| Human Swiss-Prot No. | P62753 |
| Cellular Localization | Nucleus, nucleoplasm, nucleolus, cytoplasm, cytosol, ribosome, polysome, small ribosomal subunit, membrane, cytosolic small ribosomal subunit, dendrite, intracellular ribonucleoprotein complex, cytoplasmic ribonucleoprotein granule |
| Species Reactivity | Human, Mouse, Rat |
Background
Ribosomes are organelles responsible for protein synthesis, composed of small (40S) and large (60S) subunits. The S6 protein, part of the 40S subunit, belongs to the S6E family and is a major substrate for ribosomal protein kinases. It undergoes phosphorylation on multiple serine residues in response to growth factors, mitogens, and tumor-promoting agents, while dephosphorylation occurs during growth arrest. This phosphorylation event is linked to the regulation of cell growth and proliferation through selective translation of specific mRNA classes.
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