ELK Biotechnology Rb (phospho Thr826) rabbit pAb
Retinoblastoma 단백질의 Thr826 인산화 부위를 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 적합하며 세포핵 내 Rb 단백질 검출에 유용. 인간, 생쥐, 랫트 반응성. -20°C에서 1년 보관 가능.
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제품명
Rb (phospho Thr826) rabbit pAb
대체 명칭
RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
적용 분야 (Applications)
- WB (Western Blot)
- IHC (Immunohistochemistry)
- IF (Immunofluorescence)
- ELISA
권장 희석 배수 (Recommended Dilutions)
| 응용 분야 | 희석 배수 |
|---|---|
| Western Blot | 1/500 - 1/2000 |
| Immunohistochemistry | 1/100 - 1/300 |
| Immunofluorescence | 1/200 - 1/1000 |
| ELISA | 1/10000 |
| 기타 | Not yet tested in other applications |
면역원 (Immunogen)
The antiserum was produced against a synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Thr826.
Amino Acid range: 601–650
보관 및 안정성 (Storage)
- Host: Rabbit
- Storage condition: -20°C, 1 year
항체 특성 (Antibody Characteristics)
| 항목 | 내용 |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| 농도 (Concentration) | 1 mg/ml |
| Observed Band | 110 kD |
유전자 정보 (Gene Information)
| 항목 | 내용 |
|---|---|
| Gene ID (Human) | 5925 |
| Human Swiss-Prot No | P06400 |
세포 내 위치 (Cellular Localization)
Nucleus. During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization.
배경 (Background)
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
반응 종 (Species Reactivity)
Human; Mouse; Rat
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