ELK Biotechnology Peroxin 5 rabbit pAb
Peroxin 5 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 IHC에 적합합니다. 세포 내 퍼옥시좀 단백질 수입 연구에 활용되며, 인간 및 마우스 시료에 반응합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
Peroxin 5 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PEX5; PXR1; Peroxisomal targeting signal 1 receptor; PTS1 receptor; PTS1R; PTS1-BP; Peroxin-5; Peroxisomal C-terminal targeting signal import receptor; Peroxisome receptor 1 |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from Peroxin 5 (AA range: 540–620) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 70 kDa |
| Gene ID (Human) | 5830 |
| Human Swiss-Prot No. | P50542 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cytoplasm, Peroxisome membrane; Peripheral membrane protein. Distribution appears dynamic, likely a cycling receptor mainly in cytoplasm and associated with the peroxisomal membrane via docking factor (PEX13). |
Background
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins essential for the assembly of functional peroxisomes. Peroxisome biogenesis disorders (PBDs) are genetically heterogeneous autosomal recessive diseases characterized by multiple defects in peroxisome function. These disorders include at least 14 complementation groups with varying phenotypes. Cells from PBD patients exhibit defects in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene cause neonatal adrenoleukodystrophy (NALD).
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