ELK Biotechnology Bcl-6 (phospho Ser333) rabbit pAb
Bcl-6 단백질의 Ser333 인산화 부위를 인식하는 토끼 다클론 항체로, Western blot 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 핵 내 위치 단백질 검출에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
Bcl-6 (phospho Ser333) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | BCL6; BCL5; LAZ3; ZBTB27; ZNF51; B-cell lymphoma 6 protein; BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Bcl-6 around the phosphorylation site of Ser333. AA range: 299-348 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 79 kD |
| Gene ID (Human) | 604 |
| Human Swiss-Prot No | P41182 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription and modulates the transcription of STAT-dependent IL-4 responses of B cells. It interacts with various POZ-containing proteins functioning as transcription corepressors. The gene is frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), potentially contributing to DLCL pathogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified.
[provided by RefSeq, Aug 2015]
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