Thermo Fisher Scientific p38 MAPK Polyclonal Antibody
p38 MAPK 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, IP 등 다양한 응용에 사용 가능하며 Human, Mouse, Rat 반응성을 가집니다. 액상 형태로 PBS buffer에 보관되며 연구용으로 적합합니다.
- 카탈로그번호
- PA130391
- 판매단위
- pk
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Thermo Fisher Scientific p38 MAPK Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (Mouse) identical to the corresponding human sequence |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_1959195 |
Product Specific Information
Recommended positive controls: HeLa, HL-60, and NIH/3T3.
Target Information
The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals.
p38 MAPK is relatively inactive in its nonphosphorylated form and becomes rapidly activated by dual phosphorylation of Thr-Gly-Tyr motifs.
There are four isoforms of p38 MAPK, differing in tissue expression and affinity for upstream activators and downstream effectors.
When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, MAPK kinase-3 becomes phosphorylated and activates MAPK kinase-3/6, which phosphorylate Thr180 and Tyr182 in p38 MAPK.
Activated phospho-p38 MAPK phosphorylates transcription factors such as ATF-2, CHOP-1, and MEF-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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