ELK Biotechnology PP1α (phospho Thr320) rabbit pAb

제품명

PP1α (phospho Thr320) rabbit pAb

대체 명칭

PPP1CA; PPP1A; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; PP-1A

적용 분야

• IHC
• IF
• ELISA

권장 희석 배율

면역원

The antiserum was produced against synthesized peptide derived from human PP1-alpha around the phosphorylation site of Thr320.
AA range: 281–330

보관 및 안정성

• 숙주: Rabbit
• 보관 조건: -20°C, 1년 안정

항체 특성

유전자 정보

세포 내 위치

Cytoplasm, Nucleus, Nucleoplasm, Nucleolus.
Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits.
NOM1 plays a role in targeting this protein to the nucleolus.
In the presence of PPP1R8, relocalizes from the nucleus to nuclear speckles.
Shuttles toward the cytosol during infection with VEEV (PubMed:29769351).

배경 정보

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine-specific protein phosphatase involved in regulation of various cellular processes such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription.
Increased PP1 activity has been observed in end-stage heart failure. Studies in humans and mice suggest that PP1 is an important regulator of cardiac function and may function as a suppressor of learning and memory.
Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

반응 종

Human; Mouse; Rat