ELK Biotechnology NFATc4 (phospho Ser676) rabbit pAb
NFATc4 (phospho Ser676) rabbit pAb는 인산화된 NFATc4 단백질을 검출하기 위한 고품질 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 적합하며, 사람 및 생쥐 시료에 반응합니다. 세포 내 NFAT 신호전달 연구 및 인산화 조절 메커니즘 분석에 유용합니다.
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제품명
NFATc4 (phospho Ser676) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | NFATC4; NFAT3; Nuclear factor of activated T-cells; cytoplasmic 4; NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human NFAT3 around the phosphorylation site of Ser676 (AA range: 642-691) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 120 kD |
| GeneID (Human) | 4776 |
| Human Swiss-Prot No | Q14934 |
| Species Reactivity | Human; Mouse |
세포 내 위치
Cytoplasm, cytosol, nucleus.
When hyperphosphorylated, localizes in the cytosol. When intracellular Ca(2+) levels increase, dephosphorylation by calcineurin/PPP3CA leads to translocation into the nucleus (PubMed:11997522, PubMed:18347059).
MAPK7/ERK5 and MTOR regulate NFATC4 nuclear export through phosphorylation at Ser-168 and Ser-170 (PubMed:18347059).
배경 정보
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family.
The encoded protein is part of a DNA-binding transcription complex consisting of a cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component.
NFAT proteins are activated by the calmodulin-dependent phosphatase calcineurin and play a role in the inducible expression of cytokine genes in T cells, especially interleukin-2 and interleukin-4.
Alternative splicing results in multiple transcript variants. (RefSeq, Jan 2014)
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