ELK Biotechnology PLC γ1 (phospho Tyr1253) rabbit pAb
PLC γ1 (phospho Tyr1253) rabbit pAb은 인산화된 PLCG1 단백질의 Tyr1253 부위를 인식하는 폴리클로날 항체입니다. WB 및 IHC에 적합하며, 인간, 마우스, 랫트 시료에 반응합니다. 세포 내 신호전달 연구 및 EGF 반응성 단백질 분석에 유용합니다.
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제품명
PLC γ1 (phospho Tyr1253) rabbit pAb
제품 개요
PLC γ1 (phospho Tyr1253) rabbit pAb은 인간 PLCG1 단백질의 Tyr1253 인산화 부위를 특이적으로 인식하도록 제작된 폴리클로날 항체입니다. 세포 내 인산화 신호전달 경로 연구에 활용됩니다.
주요 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PLCG1; PLC1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1 |
| Applications | WB, IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human PLCG1 around phosphorylation site Tyr1253 (AA range: 1221–1270) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 150 kDa |
| Gene ID (Human) | 5335 |
| Human Swiss-Prot No. | P19174 |
| Species Reactivity | Human, Mouse, Rat |
| Cellular Localization | Cell projection, lamellipodium, ruffle. Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. |
Background
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in intracellular transduction of receptor-mediated tyrosine kinase activators. When activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. It is also a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been identified for this gene. [RefSeq, Jul 2008]
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