ELK Biotechnology Laminin α-3 rabbit pAb
Laminin α-3 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 합성 펩타이드(AA 2571-2620)로 면역화. 세포외기질 및 기저막 단백질 연구에 적합.
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ELK Biotechnology Laminin α-3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Laminin α-3 rabbit pAb |
| Alternative Names | LAMA3; LAMNA; Laminin subunit alpha-3; Epiligrin 170 kDa subunit; E170; Epiligrin subunit alpha; Kalinin subunit alpha; Laminin-5 subunit alpha; Laminin-6 subunit alpha; Laminin-7 subunit alpha; Nicein subunit alpha |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000; IHC: 1/100–1/300; IF: 1/200–1/1000; ELISA: 1/40000; Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human LAMA3 (AA range: 2571–2620) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 120, 60 kDa |
| Gene ID (Human) | 3909 |
| Human Swiss-Prot No. | Q16787 |
| Cellular Localization | Secreted, extracellular space, extracellular matrix, basement membrane (major component) |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules composed of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. They are essential for the formation and function of the basement membrane and play roles in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit responsive to several epithelial-mesenchymal regulators, including keratinocyte growth factor, epidermal growth factor, and insulin-like growth factor. Mutations in this gene are associated with Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and promoter usage result in multiple transcript variants. (RefSeq, Dec 2014)
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