ELK Biotechnology Cleaved-Lamin A (N231) rabbit pAb
Cleaved-Lamin A (N231) rabbit pAb는 인간 Lamin A 유래 합성 펩타이드로 제작된 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 적합하며 핵막 및 라미나 단백질 검출에 활용됩니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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Cleaved-Lamin A (N231) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Cleaved-Lamin A (N231) rabbit pAb |
| Alternative Names | LMNA; LMN1; Prelamin-A/C |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Lamin A (AA range: 212–261) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| Gene ID (Human) | 4000 |
| Human Swiss-Prot No. | P02545 |
| Cellular Localization | Nucleus, nuclear envelope, nuclear lamina, nucleoplasm, and nuclear matrix. Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleavage by ZMPSTE24/FACE1 to remove the farnesyl group, producing mature lamin-A/C that integrates into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C. Isoform C: Nucleus speckle. |
| Species Reactivity | Human; Mouse; Rat |
Background
Lamin A/C (LMNA) is a component of the nuclear lamina, a two-dimensional protein matrix adjacent to the inner nuclear membrane. The lamin family proteins are highly conserved and play key roles in nuclear stability, chromatin organization, and gene expression. During mitosis, the lamina matrix is reversibly disassembled through phosphorylation of lamin proteins. Vertebrate lamins include A-type and B-type, with alternative splicing generating multiple isoforms. Mutations in LMNA are associated with several disorders, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb-girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
(Source: RefSeq, Apr 2012)
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