Thermo Fisher Scientific TIM-3 Polyclonal Antibody
TIM-3 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 및 Rat 시료에 반응합니다. Western blot과 IHC(Paraffin)에 사용 가능하며, 고순도 Affinity chromatography로 정제되었습니다. 액상 형태로 제공되며, PBS와 50% glycerol buffer에 보관됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HAVCR2 (Accession Q8TDQ0), corresponding to amino acid residues K233–Y283 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899978 |
Product Specific Information
Antibody detects endogenous levels of total HAVCR2.
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid long, Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells.
TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
It is involved in macrophage activation and induction of autoimmune diseases, down-regulates aggressive Th1-mediated immune responses, and facilitates immune tolerance.
Pathological significance of TIM3 is associated with experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, and enhances the severity of EAE in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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