Thermo Fisher Scientific CALM Polyclonal Antibody
CALM 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 IHC(P)에서 사용 가능하며, 사람·생쥐·랫트 반응성. Affinity chromatography로 정제된 액상 항체로, PBS/50% glycerol에 보관. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PICALM (Accession Q13492), corresponding to amino acid residues M617–M652 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900391 |
Product Specific Information
Antibody detects endogenous levels of total PICALM.
Target Information
PICALM (clathrin assembly lymphoid myeloid leukemia, CALM) protein co-localizes with clathrin at clathrin-coated areas of the plasma membrane and Golgi region. It plays an important role in coated pit internalization machinery.
Fusion proteins involving PICALM have been implicated in acute myeloid leukemia (AML) and T-cell acute lymphoblastic leukemia (T-ALL).
PICALM is also expressed in neurons, present at synapses facilitating endocytosis of synaptic vesicle protein VAMP2.
Recent studies have identified PICALM variants associated with Alzheimer’s disease, suggesting a role in endocytosis and recycling of the amyloid protein precursor (APP).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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