Thermo Fisher Scientific PGP9.5/UchL1 (pan-Neuronal Marker) Recombinant Rabbit Monoclonal Antibody (UCHL1/7076R)
신경세포 특이적 단백질 PGP9.5/UchL1를 인식하는 재조합 토끼 단클론 항체로, WB 및 IHC 분석에 적합. 인간과 랫트 시료에 반응하며, 고순도 Protein A/G 정제. 신경 및 신경퇴행성 질환 연구용 마커로 활용 가능.
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Thermo Fisher Scientific PGP9.5/UchL1 (pan-Neuronal Marker) Recombinant Rabbit Monoclonal Antibody (UCHL1/7076R)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | UCHL1/7076R |
| Immunogen | Recombinant full-length human UCHL1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PGP9.5 (Protein gene product 9.5, also known as UCH-L1 or PARK5) is a neuron-specific protein distinct from neuron-specific enolase. It has a molecular weight of 27 kDa and belongs to the ubiquitin carboxyl-terminal hydrolase family (peptidase family C12).
PGP9.5 exhibits ubiquitin hydrolase and ligase activities, hydrolyzing small C-terminal adducts of ubiquitin to generate monomers. It is expressed in neurons and nerve fibers throughout the central and peripheral nervous systems, as well as in neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, ova, and corpus luteum.
Overexpression of PGP9.5 is associated with non-small cell lung cancer, while decreased expression is linked to Huntington and Alzheimer diseases. As a neuronal marker, it is valuable for studies of neurodegenerative disorders such as Parkinson disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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