Thermo Fisher Scientific CD152 (CTLA-4) Monoclonal Antibody (14D3), eFluor 660, eBioscience
CD152 (CTLA-4) 단일클론 항체로 인간 및 붉은털원숭이 반응성. eFluor 660 형광 표지로 유세포분석에 최적화. 활성화 T세포의 CTLA-4 검출에 적합하며, 높은 결합 친화도와 억제 기능을 지님. 연구용으로만 사용.
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Thermo Fisher Scientific CD152 (CTLA-4) Monoclonal Antibody (14D3), eFluor 660, eBioscience
Applications and Tested Dilution
Immunohistochemistry (IHC)
- Tested dilution: 정보 없음
- View 1 publication
Flow Cytometry (Flow)
- Tested dilution: 5 µL (0.25 µg)/test
- View 12 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rhesus monkey |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control (eBM2a), eFluor 660, eBioscience |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 14D3 |
| Conjugate | eFluor™ 660 |
| Excitation / Emission Max | 651 / 668 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2574183 |
Available Formats
- Unconjugated
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 737
- Brilliant UV 805
- FITC
- Functional Grade
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Request custom conjugation
Product Specific Information
The 14D3 monoclonal antibody reacts with human CD152 (CTLA-4), a protein structurally similar to CD28. CTLA-4 is expressed on activated T cells and binds CD80 (B7-1) and CD86 (B7-2) with higher affinity than CD28.
CTLA-4 and CD28 deliver opposing signals: CD28 acts as a costimulator, while CTLA-4 inhibits T cell activation by restricting IL-2 secretion and proliferation.
A large portion of CTLA-4 is localized intracellularly due to ER retention motifs.
This antibody also recognizes rhesus monkey CTLA-4 and exhibits inhibitor activity.
Applications Reported: Intracellular staining followed by flow cytometric analysis.
Applications Tested: Pre-titrated and validated using the Intracellular Fixation & Permeabilization Buffer Set (Product #88-8824-00).
For complete detection, assess both surface and intracellular CTLA-4 expression.
eFluor® 660 replaces Alexa Fluor® 647.
- Excitation: 633–647 nm
- Emission: 668 nm
- Laser: Red Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed mainly on CD4+ T cells. It binds CD80 and CD86 with higher affinity than CD28, inhibiting T cell activation. Intracellular CTLA4 is also present in regulatory T cells and contributes to their suppressive function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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