Thermo Fisher Scientific VEGFB Polyclonal Antibody
VEGFB 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. Human, Mouse, Rat 반응성을 가지며, 고순도 Affinity chromatography로 정제되었습니다. VEGFB 관련 혈관생성 연구에 활용 가능합니다.
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- PA599560
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human VEGFB (Accession P49765), corresponding to amino acid residues R105–S155 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818493 |
Product Specific Information
Antibody detects endogenous levels of total VEGFB.
Target Information
Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors characterized by eight conserved cysteine residues and common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis.
VEGFB shares structural similarity with VEGF and PIGF and is often co-expressed with VEGF. Two isoforms exist: VEGFB 167 (heparin-binding, cell-associated) and VEGFB 186 (secreted).
VEGFB stimulates endothelial cell proliferation and binds specifically to VEGFR1 (flt1), not VEGFR2. It is widely expressed, especially in heart, skeletal muscle, and pancreas. VEGFB expression in human primary breast cancers has been linked to lymph node metastasis.
The VEGFB gene is mapped to chromosome 11q13.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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