Thermo Fisher Scientific ATG13 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000
• Publications: View references

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:200
• Publications: View references

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen, and the purity is >95% (by SDS-PAGE).

Target Information

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions and in the normal turnover of cytosolic components.
This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1, ULK2 (mammalian homologs of ATG1), and FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1, and ULK2, which then triggers autophagy. Knockdown of ATG13 inhibits autophagosome formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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