Thermo Fisher Scientific Human MERTK (cMER), GST Tag Recombinant Protein
Human MERTK (cMER) 단백질은 GST 태그로 정제된 재조합 단백질로, 인산화효소 활성 분석(Kinase Assay)에 적합합니다. 인간 유래 단백질로 세포 생존, 이동, 분화 및 식세포 작용 연구에 활용됩니다. -80°C 보관 시 6개월 안정성 보장.
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human MERTK (cMER), GST Tag Recombinant Protein
Thermo Fisher Scientific Human MERTK (cMER), GST Tag Recombinant Protein
Applications
- Kinase Assay (KA)
Tested Dilution: Assay-dependent
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Amino acid sequence | 578–872 |
| Tag | GST-tag |
| Molecular Weight | 63.4 kDa |
| Class | Recombinant |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris-HCl (pH 7.5), 50% glycerol, 0.02% Triton X-100, 150 mM NaCl, 0.5 mM EDTA, 2 mM DTT |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
- For maximum recovery, spin prior to use.
- Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
- For larger sizes, aliquot preparation can reduce freeze/thaw cycles (avoid aliquots below 20 µL).
- Never store kinase diluted.
- Properly stored at -80°C, guaranteed for 6 months from date of purchase.
- Protein Form: Cytoplasmic
Target Information
MERTK (cMER) is a tyrosine kinase proto-oncogene involved in the retinal pigment epithelium (RPE) phagocytosis pathway, implicated in human retinal disease. It regulates cell survival, migration, differentiation, and efferocytosis. Ligand binding induces autophosphorylation and downstream signaling through GRB2 or PLCG2, activating MAPK1, MAPK2, FAK/PTK2, or RAC1. MERTK plays critical roles in macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and inhibition of Toll-like receptor-mediated innate immune responses via STAT1 activation and SOCS1/SOCS3 induction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.