Thermo Fisher Scientific CD40/TNFRSF5/CD40L-Receptor Recombinant Rabbit Monoclonal Antibody (C40/4826R)

Applications and Tested Dilution

Product Specifications

Target Information

The CD40 antigen is a single-chain glycoprotein belonging to the tumor necrosis factor/nerve growth factor superfamily. It shows significant homology to the Hodgkin’s disease-associated antigen CD30. CD40 is expressed on all B cells except plasma cells and is also found on some epithelial cells, carcinomas, and lymphoid dendritic cells.

CD40 plays a crucial role in immune and inflammatory responses, including:

• T cell-dependent immunoglobulin class switching
• Memory B cell development
• Germinal center formation

The AT-hook transcription factor AKNA regulates CD40 expression, influencing homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40, mediating signal transduction. The CD40–CD40L interaction is essential for amyloid-beta-induced microglial activation, implicated in early Alzheimer’s disease pathogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.

Diseases associated with CD40 dysfunction include:

• Type 3 Hyper-IgM immunodeficiency
• CD40 ligand deficiency

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.