Thermo Fisher Scientific CD40/TNFRSF5/CD40L-Receptor Monoclonal Antibody (C40/2383)

Applications and Tested Dilutions

Product Specifications

Target Information

The CD40 antigen is a single-chain glycoprotein and a member of the tumor necrosis factor/nerve growth factor superfamily. It shows significant homology to the Hodgkin’s disease-associated antigen CD30. CD40 is present on all B cells except plasma cells and is also expressed on some epithelial cells, carcinomas, and lymphoid dendritic cells. It plays essential roles in immune and inflammatory responses, including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.

The AT-hook transcription factor AKNA regulates CD40 expression, which is important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 to mediate signal transduction. The CD40-CD40L interaction is necessary for amyloid-beta-induced microglial activation, an early event in Alzheimer’s disease pathogenesis. Two alternatively spliced transcript variants encoding distinct isoforms of CD40 have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-IgM immunodeficiency and CD40 ligand deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.