Thermo Fisher Scientific Bcl-6 Recombinant Rabbit Monoclonal Antibody (BCL6, 2497R)
Recombinant Rabbit Monoclonal Antibody targeting Bcl-6 (BCL6, 2497R). Validated for IHC (Paraffin) applications. Reacts with human and dog samples. High purity (Protein A/G) and stable liquid form (200 µg/mL). For research use only.
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- 604-RBM13-P0
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BCL6, 2497R |
| Immunogen | Recombinant human Bcl-6 protein fragment (aa256–389) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Bcl-6 proto-oncogene product is a Kruppel-type zinc-finger protein mainly expressed in normal germinal center B cells and related lymphomas.
It is involved in chromosome rearrangements at 3q27 in non-Hodgkin’s lymphomas, with rearrangements detected in 33–45% of diffuse large B cell lymphomas.
Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt’s lymphomas, and nodular lymphocyte predominant Hodgkin’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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