Thermo Fisher Scientific Phospho-c-Myc (Ser62) Recombinant Rabbit Monoclonal Antibody (ARC1533)
Recombinant rabbit monoclonal antibody recognizing phospho-c-Myc (Ser62). Validated for WB and ELISA in human and mouse samples. High purity, affinity-purified, liquid form with 1.5 mg/mL concentration. Ideal for research on cell proliferation and onco...
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1533 |
| Immunogen | Synthetic phosphorylated peptide around Ser62 of human c-Myc (NP_0024582) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898145 |
Product Specific Information
- Positive Samples: 293T, NIH/3T3
- Immunogen sequence: PLSPS
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays a crucial role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK regulates c-Myc function. c-Myc is essential for vasculogenesis and angiogenesis during tumor development.
Deregulated expression of c-Myc induces apoptosis and contributes to neoplastic diseases. Amplification or translocation of the c-Myc gene is associated with multiple cancers, including Burkitt’s lymphoma, lung, breast, and colon carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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