Thermo Fisher Scientific NR5A1 Polyclonal Antibody
Human SF-1을 인식하는 Rabbit Polyclonal Antibody로, IHC 및 IHC (Paraffin) 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS에 0.1% sodium azide가 포함된 액상 형태. SF-1 관련 내분비 기관 발달 및 스테로이드 합성 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 7 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide, KLH conjugated, corresponding to the ligand-binding domain of human SF-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2267358 |
Product Specific Information
Sequence identity/similarity to Mouse: 93/93%.
Sequence identity/similarity to Rat: 93/93%.
Target Information
Steroidogenic factor-1 (SF-1) is an orphan nuclear receptor involved in organ development and differentiation of the endocrine system.
SF-1 is essential for fetal development of the hypothalamus, pituitary gland, gonads, and the adrenal gland.
It promotes transcriptional activity of many steroidogenic enzymes from the cytochrome P450 family.
SF-1 contains two activation function domains (AF1 and AF2), necessary for interactions with other nuclear receptors as well as coactivators and corepressors such as:
- Steroid receptor coactivator-1 (SRC-1)
- Glucocorticoid receptor interacting protein 1 (GRIP1)
- cAMP response element binding protein (CREB) binding protein (CBP)
- Silencing mediator of retinoid acid and thyroid hormone receptor (SMRT)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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