Thermo Fisher Scientific RhoGAP Polyclonal Antibody
RhoGAP 단백질을 표적으로 하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB 및 IHC(P) 실험에 적합합니다. 인간, 생쥐, 랫트에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PA582344
- 판매단위
- pk
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Thermo Fisher Scientific RhoGAP Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARHGAP1 (Product #RP-102446) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789503 |
Product Specific Information
Immunogen sequence:
DFDQYNELHL PAVILKTFLR ELPEPLLTFD LYPHVVGFLN IDESQRVPAT LQVLQTLPEE NYQVLRFLTA FLVQISAHSD QNKMTNTNLA VVFGPNLLWA KDAAITLKAI NPINTFTKFL LDHQGELF
Target Information
The p190 RhoGAP protein is associated with p120 RasGAP in growth-factor stimulated and tyrosine kinase transformed cells. It functions as a GTPase-activating protein (GAP) for Rho and Rac family proteins, which are involved in regulating cytoskeletal actin and membrane ruffling. The antibody appears to couple signal transduction via Ras and Rho through its association with RasGAP. The presence of two adjacent SH2 domains in the p21 RAS GAP indicates that GAP might interact directly with tyrosine kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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