Thermo Fisher Scientific RhoGAP Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ARHGAP1. Recombinant protein control fragment (Product #RP-102446). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RhoGAP,uniProtId:Q07960-1,ncbiNodeId:9606,antigenRange:304-431,antigenLength:439,antigenImageFileName:PA5-82344_RhoGAP_Q07960-1_Rabbit.svg,antigenImageFileNamePDP:PA5-82344_RhoGAP_Q07960-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2789503

Product Specific Information

Immunogen sequence: DFDQYNELHL PAVILKTFLR ELPEPLLTFD LYPHVVGFLN IDESQRVPAT LQVLQTLPEE NYQVLRFLTA FLVQISAHSD QNKMTNTNLA VVFGPNLLWA KDAAITLKAI NPINTFTKFL LDHQGELF

Target Information

The p190 RhoGAP protein is associated with p120 RasGAP in growth-factor stimulated and tyrosine kinase transformed cells. It functions as a GTPase - activating protein (GAP) for Rho and Rac family proteins, which are involved in regulating cytoskeletal actin and membrane ruffling. The antibody appears to couple signal transduction via Ras and Rho through its association with RasGAP. The presence of two adjacent SH2 domains in the p21 RAS GAP indicates that GAP might interact directly with tyrosine kinases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.