Thermo Fisher Scientific alpha Actinin 2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ACTN2. Recombinant protein control fragment (Product #RP-102321). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:alpha Actinin 2,uniProtId:P35609-1,ncbiNodeId:9606,antigenRange:557-698,antigenLength:894,antigenImageFileName:PA5-82346_alpha_Actinin_2_P35609-1_Rabbit.svg,antigenImageFileNamePDP:PA5-82346_alpha_Actinin_2_P35609-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2789505

Product Specific Information

Immunogen sequence: AHEQFKATLP EADGERQSIM AIQNEVEKVI QSYNIRISSS NPYSTVTMDE LRTKWDKVKQ LVPIRDQSLQ EELARQHANE RLRRQFAAQA NAIGPWIQNK MEEIARSSIQ ITGALEDQMN QLKQYEHNII NYKNNIDKLE GD

Target Information

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it i involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.