Thermo Fisher Scientific CALM Polyclonal Antibody
CALM 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 적용 가능. Human, Mouse, Rat 반응성. 고순도 항원 친화 크로마토그래피 정제. Alzheimer’s 연구 및 단백질 내재화 기전 연구에 활용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PICALM. Recombinant protein control fragment (Product #RP-92550) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789817 |
Product Specific Information
Immunogen sequence:
DIPDLSQAPS SLLDALEQHL ASLEGKKIKD STAASRATTL SNAVSSLAST GLSLTKVDER EKQAALEEEQ ARLKALKEQR L
Target Information
PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area. It is an important component of the coated pit internalization machinery.
Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia.
PICALM is also expressed in neurons and facilitates endocytosis of the synaptic vesicle protein VAMP2.
Variants of PICALM have been associated with Alzheimer’s disease and may play a role in endocytosis and recycling of the amyloid precursor protein (APP).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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