Thermo Fisher Scientific APBA1/MINT1 Polyclonal Antibody
APBA1/MINT1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 인간 시료에 반응하며 4°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 75 to 125 of human Amyloid beta A4 precursor protein-binding family A member 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
The Munc-18 interacting protein (Mint) family comprises evolutionarily conserved adaptor proteins involved in membrane transport and organization. Mammals express three isoforms—Mint1, Mint2, and Mint3. The C-terminal halves of these proteins are highly conserved and contain phosphotyrosine-binding (PTB) and PSD-95/DLG-A/ZO-1 (PDZ) domains, which serve as protein interaction modules.
Mint1 and Mint2 are expressed primarily in the brain and interact with Munc18, a critical component of synaptic vesicle fusion. Mint3, however, is ubiquitously expressed, with the lowest levels in the brain and testis, and does not interact with Munc18. Mint3 associates with the Alzheimer’s disease-related amyloid precursor protein (APP) through its PTB and PDZ domains, linking APP to transport machinery components that regulate its trafficking, endocytosis, and metabolism. Abnormal APP metabolism is implicated in early-onset Alzheimer’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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