Thermo Fisher Scientific NTHL1 Polyclonal Antibody
Thermo Fisher Scientific의 NTHL1 Polyclonal Antibody는 인간 NTHL1 단백질을 표적으로 하는 토끼 유래 다클론 항체입니다. 산화적 DNA 손상 복구 연구에 적합하며, IP 등 다양한 응용에 사용 가능합니다. 액상 형태로 4°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Between amino acids 150–200 of human NTHL1 (UniProt ID: P78549-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Oxygen radicals damage chromosomal DNA, causing cell death and inducing mutations. Although much focus has been placed on the repair of 8-oxo-G, many other damaged DNA sites are created by free-radical attack.
The human NTH1 repair protein acts on a wide range of oxidatively damaged DNA sites. A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity.
NTH protein exhibits broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates that NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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