Thermo Fisher Scientific DREF Polyclonal Antibody
Thermo Fisher Scientific DREF Polyclonal Antibody는 인간 및 마우스 시료에 반응하는 Rabbit IgG 기반 항체입니다. Western blot에 적합하며, A549 lysate를 양성 대조로 사용할 수 있습니다. ZBED1(DREF) 단백질 연구 및 세포 증식 관련 유전자 발현 분석에 유용합니다.
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Thermo Fisher Scientific DREF Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1 µg/mL
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the center of human ZBED1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154385 |
Product Specific Information
- A suggested positive control is A549 cell lysate.
- PA5-20732 can be used with blocking peptide PEP-0846.
Target Information
ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation.
RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 plays a role in cell proliferation in human cells.
At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression.
Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, which is required for nuclear localization and DNA binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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