Thermo Fisher Scientific FKBP15 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

Immunohistochemistry (IHC)

• Tested Dilution: 2.5 µg/mL

Product Specifications

Product Specific Information

• A suggested positive control is NIH-3T3 cell lysate.
• PA5-20730 can be used with blocking peptide PEP-0844.

Target Information

FKBP15, also known as FKBP133, belongs to the FK506-binding protein family, initially identified as immunophilins—targets for immunosuppressant drugs FK506 and Rapamycin.
FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) along with the FK506-binding motif.
It is distributed along axonal shafts and partially co-localizes with F-actin in growth cones of dorsal root ganglion neurons. Overexpression of FKBP15 increases filopodia formation, suggesting its role in modulating growth cone behavior.
FKBP15 associates with microtubules and actin filaments; RNAi disruption delays early endosome transport in HeLa cells, indicating involvement in endosomal trafficking.
At least three isoforms of FKBP15 are known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.