Thermo Fisher Scientific FKBP15 Polyclonal Antibody
FKBP15 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합. 인간, 마우스, 랫트 반응성. 액상 형태, 항원 친화 크로마토그래피로 정제. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the amino terminus of human FKBP15 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153326 |
Product Specific Information
- A suggested positive control is NIH-3T3 cell lysate.
- PA5-20730 can be used with blocking peptide PEP-0844.
Target Information
FKBP15, also known as FKBP133, belongs to the FK506-binding protein family, initially identified as immunophilins—targets for immunosuppressant drugs FK506 and Rapamycin.
FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) along with the FK506-binding motif.
It is distributed along axonal shafts and partially co-localizes with F-actin in growth cones of dorsal root ganglion neurons. Overexpression of FKBP15 increases filopodia formation, suggesting its role in modulating growth cone behavior.
FKBP15 associates with microtubules and actin filaments; RNAi disruption delays early endosome transport in HeLa cells, indicating involvement in endosomal trafficking.
At least three isoforms of FKBP15 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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