Thermo Fisher Scientific HAVCR1 Monoclonal Antibody (2B9)
HAVCR1(KIM-1/CD365) 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 ELISA에 사용 가능. 인간 시료 반응성, 비결합형 액상 형태. 친화 크로마토그래피로 정제되었으며 PBS(pH 7.4)에 보존. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 10 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B9 |
| Immunogen | HAVCR1 (NP_036338, 23 a.a. ~ 122 a.a) partial recombinant protein with GST tag. MW of GST tag alone: 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
KVGGEAGPSV TLPCHYSGAV TSMCWNRGSC SLFTCQNGIV WTNGTHVTYR KDTRYKLLGD LSRRDVSLTI ENTAVSDSGV YCCRVEHRGW FNDMKITVSL
Target Information
CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein with an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
The endogenous ligand for CD365 is Tim-4. CD365 acts as a receptor or co-receptor for various viruses including hepatitis A/C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses, binding to phosphatidylserine on viral envelopes.
Polymorphisms within the human CD365 gene (HAVCR1) are associated with infection susceptibility and disease severity. CD365 is also implicated in T-cell co-stimulation. It is primarily expressed in epithelial cells and highly expressed in A549, 769-P, and Caco-2 cell lines. Soluble forms exist due to metalloproteinase-mediated cleavage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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